Find a comprehensive guide to possible side effects including common and rare side effects when taking Sprintec (Norgestimate and Ethinyl Estradiol Tablets) for healthcare professionals and consumers. Drospirenone and Ethinyl Estradiol tablets are indicated for use by women to prevent pregnancy. Drospirenone and Ethinyl Estradiol Dosage and Administration Cigarette smoking increases the risk of serious side effects from oral contraceptives, including heart attacks, blood clots, and strokes. This risk is higher for women over 35 years of age and heavy smokers (15 or more cigarettes per day). Learn about the potential side effects of ethinyl estradiol/norethindrone. Includes common and rare side effects information for consumers and healthcare professionals. Lo Loestrin Fe (norethindrone acetate and ethinyl estradiol, ethinyl estradiol tablets) is a packet of two combination drugs and two placebo tablets used for prevention of pregnancy in women.